The Importance of Sleep.

band, laparoscopic sleeve gastrectomy, and Roux-en-Y gastric bypass. Although these procedures have been shown to achieve sustained weight loss and decreased mortality and morbidity, they can also cause unintended effects on the esophagus involving gastroesophageal reflux disease and esophageal motility. Our endoscopy column also involves bariatric procedures. Dr Christopher C. Thompson discusses evolving techniques for bariatric endoscopy (intragastric balloon and endoscopic gastroplasty) as well as bariatric surgery. In the GERD column, Dr John E. Pandolfino examines the treatment of gastroesophageal reflux disease using endoscopy and radiofrequency ablation. In the Hepatology column, Dr Marlyn J. Mayo discusses the creation and use of the new GLOBE score to predict outcomes of primary biliary cholangitis. The bimonthly HCC in Focus column features an interview with Dr Ghassan K. Abou-Alfa on the emerging use of genetic alterations to develop liver cancer drugs. Our Clinical Update column is based on part of a presentation from the recent American College of Gastroenterology meeting, in which Dr Gerald W. Dryden explored the management of inflammatory bowel disease using biologic therapies. In our occasional brief case study section, Drs Alhareth M. Al Juboori, Zeeshan Afzal, and Nisar Ahmed highlight an interesting case of esophageal squamous cell papilloma that caused dysphagia. I hope that this issue provides valuable insights for your clinical practice.